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Univ. of Nev. School of Medicine, Family Medicine Yes, there are several medications that can help with the symptoms of IBS that you can obtain over the counter. It depends to some extent on the type of IBS you have. 2014-10-22 · In irritable bowel syndrome (IBS) patients with diarrhea, antidiarrheal agents such as loperamide and diphenoxylate can be effective in decreasing bowel movement frequency, improving stool form by enhancing intestinal water and ion absorption, and increasing anal sphincter tone at rest. Antibiotics - Antibiotics used in the treatment of IBS include rifaximin (Xifaxan). IBS-specific prescription medications - Several medicines are approved specifically for IBS. These are usually prescribed only when lifestyle changes and other treatments have not been successful.
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